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As might be anticipated, early-onset hydrocephalus alters the entire process of brain development resulting in irreparable neurologic shortage. A primary alteration regarding the ependyma/neural stem cells (affecting vesicle trafficking and abnormal cellular junctions) results in its loss or denudation and translocation of neural progenitor cells (NPCs) and neural stem cells (NSCs) into the cerebrospinal liquid (CSF). Under these unusual circumstances, morphological and functional procedures, fundamental the conc