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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the ongoing coronavirus disease 2019 (COVID-19) pandemic. Alongside investigations into the virology of SARS-CoV-2, understanding the fundamental physiological and immunological processes underlying the clinical manifestations of COVID-19 is vital for the identification and rational design of effective therapies. Here, we provide an overview of the pathophysiology of SARS-CoV-2 infection. We describe the interaction of SARS-CoV-2 with the immune system

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53, 95%CI 1.29-1.77; FHR-BP observed mean 1.56, 95%CI 1.26-1.85; PBCs observed mean 0.99, 95%CI 0.82-1.17; p.001). Binary logistic regression showed that the lifetime risk of exposure to interpersonal trauma (age 0-11years) was elevated for both FHR-groups (FHR-SZ OR 3.773, 95%CI 2.122-6.710, p.001; FHR-BP OR 3.602, 95%CI 1.913-6.783, p.001). Children at FHR-SZ and FHR-BP are at increased risk for being exposed to childhood trauma compared with PBCs. This study underscores the need for early detection, support, and