https://www.selleckchem.com/pr....oducts/epalrestat.ht
BACKGROUND Hyperfiltration (HF) occurs early in diabetes or obesity (O-associated renal disease. Alterations of glomerular filtration rate (GFR) in childhood OB remain unclear. OBJECTIVES To compare the prevalence of GFR alterations and its association with uric acid in children and adolescents with type 1 diabetes (T1D) vs overweight (OW)/OB. METHODS Cross-sectional study of 29 youths (aged 13 ± 2 years) with T1D (disease duration 7 ± 3 years) and 165 with OW/OB (aged 11 ± 3 years). Patients with an albumin-creatinine ratio 3.

https://www.selleckchem.com/pr....oducts/l-mimosine.ht
Muscle weakness in idiopathic inflammatory myopathies (IIMs) is conventionally assessed using manual muscle testing (MMT). However, more objective tools must be developed to accurately and reliably quantify muscle strength in myositis patients. Hand-held dynamometry (HHD) is a quantitative, portable device with reported reliability in neuromuscular disorders. Our aim was to assess the reliability, validity and responsiveness of HHD in myositis. Myositis patients [DM, necrotizing myopathy (NM), PM and anti-synthetase syndrome] evaluat