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Gaggia Brera Espresso Review Among the more versatile automatic bean-to-cup machines on the market, the Brera uses a lots of personalization options. It uses ceramic burrs to grind the beans which reduces heat and assists keep the scent. Another great function is the simple dosing. You pick the wanted quantity of beans using a button and the machine automatically re

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We previously reported the development of a novel formulation of an ultra-long-acting local anesthetic based on bupivacaine encapsulated in large multivesicular liposomes (Bupisomes) embedded in hydrogel. This formulation (Bupigel) prolonged bupivacaine release from the formulation in dissolution-like studies in vitro and analgesia in vivo in mouse, rat, and pig models. In this study we assessed Bupigel neurotoxicity on rabbit sciatic nerve using histopathology and electrophysiologic testing. Sciatic nerves of both hind limb