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Conclusions These cross-sectional findings support that in adults who are overweight or obese but otherwise relatively healthy, LVM is associated with both body composition and cardiorespiratory fitness. This may indicate the need to reduce body fatness and improve fitness for patients with obesity to enhance cardiovascular structure and function. © 2019 The Authors Obesity Science Practice published by World Obesity and The Obesity Society and John Wiley Sons Ltd.Background Most adults with overweight/obesity participating