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Another CDK7 inhibitor, LDC4297, also potently interfered with the expression of mutated p53. Furthermore, endogenous CDK7 expression was positively correlated with the levels of mutated p53 in TNBC cells with p53 mutation. Downregulating mutated p53 expression significantly suppressed the proliferation of TNBC cells with p53 mutation. Our findings demonstrated that targeting CDK7 was an effective approach for the treatment of TNBC with p53 mutation. Our findings demonstrated that targeting CDK7 was an effective appro