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In addition, the ion valences also modify the electrophoretic and chemiphoretic contributions to the diffusiophoretic mobility of the particles. Our results are applicable to systems where the chemical concentration gradient is comprised of multivalent ions, and motivate future research to manipulate particles by exploiting ion valence.While recognized as a therapeutic target, the spliceosome may offer a robust vector to improve established therapeutics against other protein targets. Here, we describe how modulating the spliceosome usin

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7% (6/9. The prevalence of karyotypic abnormalities or FMR1 premutation did not differ significantly between familial and sporadic cases. Neither chromosome abnormalities nor FMR1 premutation influenced age at menopause or follicle stimulating hormone levels at diagnosis in premature ovarian insufficiency patients. This is the first study describing the clinical characteristics and both cytogenetic and FMR1 testing in a Portuguese population with premature ovarian insufficiency. The rate of chromosome abnormalities in our sample was h