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The greater serum sodium changes during CRRT were associated with higher 90-mortality (OR 1.35; 95% CI 1.21-1.51 per 5-mmol/L increase). Before CRRT initiation, hypernatremia and during CRRT, hypo- and hypernatremia were associated with increased mortality. Before CRRT initiation, hypernatremia and during CRRT, hypo- and hypernatremia were associated with increased mortality. With the availability of T-cell-directed therapy and next-generation compounds of established classes of drugs, the treatment of relapsed/refractory (r/r) myeloma