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ADHD Medications - Stimulant Or Non Stimulant? Stimulant medications are the first-choice ADHD treatment, since they are the most researched and have a rapid-acting effect. But they're not for everyone. These medications enhance the signaling between nerves and brain regions to reduce ADHD symptoms. can also cause negative side effects, such as a rise in heart rate or blood pressure and the loss of appetite. Stimulants The most commonly used medication to treat ADHD is stimulants. They are known for enh