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ADHD Medications - Stimulant Or Non Stimulant? Stimulant medication is the first-choice treatment for ADHD and for a lot of people, they are effective. Some people have side effects or they don't work. Some doctors prescribe stimulants along with non-stimulant ADHD medications. These medications include those that treat high blood pressure, for instance the clonidine drug and guanfacine HCL (Tenex). These are among the other medications that aid in promoting the state of being awake.