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The Most Effective ADHD Medication For Adults The majority of ADHD medications fall into two categories: stimulants and non-stimulants. Stimulants like methylphenidate (Provigil) and amphetamines work by enhancing the activity of parts of the brain responsible for the behaviour and attention. Non-stimulants, like atomoxetine (Strattera) as well as Guanfacine (Intuniv) and clonidine (Kapvay), work slower than stimulants b