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ADHD Medications - Stimulant Or Non Stimulant? For many stimulant medication is the first choice for treating ADHD. Certain people experience side effects or they don't work. Some doctors prescribe stimulants in addition to non-stimulant ADHD medications. These include medications that treat high blood-pressure like clonidine and guanfacine (Tenex). They also include other medications that act to promote wakefulness. Benefits The first drug doctors prescribe to treat ADHD is stimulants. They