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Stimulants Are the Most Effective ADHD Medication For Adults The most frequently prescribed medication prescribed by health professionals to treat ADHD in adults is stimulants. They increase the levels of certain chemicals (neurotransmitters) in your brain to improve attention and reduce the amount of impulsivity. Antidepressants such as Strattera (atomoxetine) and Wellbutrin/Zyban (bupropion) also help control ADHD. They increase levels of norepinephrine in the brain. Stimulants Stimulants are the