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Does ADHD Medication Work? When someone gets a prescription for ADHD medication, they usually worry about whether it will be effective and how long it will last. Here are some simple answers. Stimulants work by adjusting levels of brain chemicals that transmit messages regarding attention and activity. They include dopamine and norepinephrine. They are the first-line treatment for adults suffering from ADHD. 1. Stimulants Stimulants are commonly used to treat ADHD. They alter the activity of n