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How Does ADHD Medication Work? ADHD is treated with stimulants. They regulate the levels of neurotransmitters (two brain chemicals) that transmit messages between neurons in order to improve attention and decrease excessive hyperactivity. 20 % of people are not sensitive to stimulants such as methylphenidate or amphetamine. This could be due to the body's chemistry of the individual or other medications that they are taking. What are the symptoms ADHD? Talk to your child's doctor in the event t