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Early onset infection (EOI) in gastroschisis is rare. Excess antibiotic exposure in neonates increases necrotizing enterocolitis and mortality. We evaluated antibiotic exposure and EOI in gastroschisis. Retrospective cohort analysis between 2010-2016 in the Children's Hospital Neonatal Database. Included Infants ≥32 weeks with gastroschisis admitted 48 h. Excluded major anomalies or surgical intervention prior to admission. EOI diagnosis (72 h). In 2021 patients with gastroschisis, median gestational age wa