https://www.selleckchem.com/Proteasome.html
05; Combination Index 0.44 ( less then 1 indicates synergy). In vivo, Lef alone and in combination with Gem delays KPC tumor progression (P less then 0.001). CTLA-4+T cells are also significantly decreased in tumors treated with Lef, Gem or in combination (Gem+Lef) compared to controls (P less then 0.05). Combination therapy also decreased the Ki67 and vascularity (P less then 0.01). Leflunomide inhibits de novo pyrimidine synthesis both in vitro (p less then 0.0001) and in vivo (p less then 0.05). Conclusions In this study, we demonstrated t
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