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A literature review showed that some of those predicted drug synergies have-been identified in vivo or in vitro. Therefore , the DTF model could be a very important in silico tool for prioritizing unique synergistic drug combinations. AVAILABILITY Origin code and data is available at https//github.com/ZexuanSun/DTF-Drug-Synergy. SUPPLEMENTARY IDEAS Supplementary data can be found at Bioinformatics on line. © The Author(s) (202. Posted by Oxford University Press