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y may have actively contributed to her healing process through episodic CAM practice. Cyclic psychophysiological response patterns following CAM practice were attributable to biopsychosocial feedback mechanisms involving personally meaningful experiences. As lower neopterin levels following CAM point to a health-promoting effect, the patient of this study may have actively contributed to her healing process through episodic CAM practice.This longitudinal study examined whether the cognitive and academic development of children (Mage = 10.5