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All of the mutant isolates had numerous point mutations in the place of solitary point mutation in pvmdr1 (41/44) and pvdhfr (19/21). One book point mutation V111I was detected in pvdhfr. Allelic combo evaluation reveals considerable strong relationship between mutations in pvcrt-o and pvmdr1 (X2 = 9.521, P less then 0.05). In today's research, 65.9% regarding the customers tend to be non-Malaysians, with handful of all of them arrived in Malaysia 1-2 months before the o