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This diary is © The Royal community of Chemistry 2019.The 5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine derivative BIM-46174 has received interest as Gαq inhibitor. We carried out structural reductions to monocyclic and bicyclic substructures to explore the substance area of BIM fragments and also to get insights into the pharmacophore of BIM-type Gαq inhibitors. Two piperazin-2-one-containing fragments and a small library of bicyclic lactams featuring fused pyrazine and diaz
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