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Background Appropriate patient selection is critical for successful deep brain stimulation (DBS) for Parkinson's disease (PD). Subcortical atrophy is a possible determinant of postoperative DBS outcomes in patients with idiopathic PD, but it has not been well evaluated for DBS of the globus pallidus interna (GPi). We investigated perioperative subcortical atrophy measures in PD patients and their relationship to postoperative motor response in bilateral GPi-targeted DBS. Methods A retrospective cohort study examined correlations among

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We found that NLR family pyrin domain containing 3 (NLRP3) was the most studied, followed by NLRP1, NLRP2, and NLRC4 among the inflammasomes associated with stroke. Analysis of keywords suggested that the most studied mechanisms involved dysregulation of extracellular pH, efflux of Ca ions, dysfunction of K /Na ATPases, mitochondrial dysfunction, and damage to mitochondrial DNA. Given the potential diagnostic and therapeutic implications, the specific mechanisms of inflammasomes contributing to stroke warrant further investigation. We use