https://www.selleckchem.com/pr....oducts/hpk1-in-2.htm
Synthesizing findings about the indirect (mediated) effect plays an important role in determining the mechanism through which variables affect one another. This simulation study compared six methods for synthesizing indirect effects correlation-based MASEM, parameter-based MASEM, marginal likelihood synthesis, an adjustment to marginal likelihood synthesis, and univariate, and two-parameter sequential Bayesian methods. This paper provides an empirical example and code for using all methods compared in the simulation study. The methods

https://www.selleckchem.com/pr....oducts/s-2-hydroxysu
Chronic pain, encompassing conditions, such as low back pain, arthritis, persistent post-surgical pain, fibromyalgia, and neuropathic pain disorders, is highly prevalent but remains poorly treated. The vast majority of therapeutics are directed solely at neurons, despite the fact that signaling between immune cells, glia, and neurons is now recognized as indispensable for the initiation and maintenance of chronic pain. This review highlights recent advances in understanding fundamental neuroimmune signaling mechanisms a