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1 levels in a small proportion of CTCL patients do not support an essential role for IL31 in CTCL patients. Translational and transcriptional expression levels of IL31 were very low or undetectable in CTCL patients. Detectable low IL31 serum levels were exclusively observed in SS and FMF patients and not in patients with classic MF. However, these marginal IL31 levels in a small proportion of CTCL patients do not support an essential role for IL31 in CTCL patients. Immortalized mammalian cell lines are a valuable research tool, though the

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ecial education centers' supplementary curriculum and training materials, making new enhancements and improvements possible in the future. Both the educators and the children with SpLD enjoyed playing the games, gave positive feedback, and suggested new ways for improvement. The results showed that these games provide thorough training material for different types of SpLD with personalized and tailored difficulty systems. The final version of the proposed games will become a part of the special education centers' supplemen