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Genetic tools to study gene function and the fate of cells in the anterior limb bud are very limited. We describe a transgenic mouse line expressing CreER from the Aristaless-like 4 (Alx4) promoter that induces recombination in the anterior limb. Cre induction at embryonic day 8.5 revealed that Alx4-CreER labeled cells using the mTmG Cre reporter contributed to anterior digits I to III as well as the radius of the forelimb. Cre activity is expanded further along the AP axis in the hindlimb than in the forelimb resulting in some Cre rep

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Choosing a Mattress Double Bed When choosing a mattress, the size is an important aspect. While double mattresses are a great choice for singles who want a bigger mattress, couples might prefer the king or California size mattresses. The terms "double" and "full size" are frequently used interchangeably, but they are both referring to the same size mattress. Find out more about this