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8%) were enrolled; 34 (57%) were ablated in RVOT septum and 26 (43%) patients in the RVOT free wall area. Propensity match with 60 non-AI-guided patients was performed. Acute outcomes and complications resulted comparable. At 6 months, arrhythmic recurrence was more common in non-AI-guided patients whether in general (28% vs. 7% P = 0.003) or by ablated area (RVOT free wall 27% vs. 4%, P = 0.06; RVOT septum 29% vs. 9% P = 0.05). Ablation Index guidance was associated with improved survival from arrhythmic recurrence [overall odds ratio

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Epigenetic legislation plays a vital role in managing fungal secondary metabolism. Right here, we report the pleiotropic effects of the epigenetic regulator HdaA (histone deacetylase) on secondary metabolite production while the linked biosynthetic gene groups (BGCs) appearance within the plant endophytic fungus Penicillium chrysogenum Fes1701. Deletion of this hdaA gene in stress Fes1701 induced a substantial modification regarding the a