https://www.selleckchem.com/pr....oducts/pf-04957325.h
The mean 2.5-year follow-up revealed 143 ischemic strokes and 332 bleeding events. Annual event rates were 0.58% for ischemic stroke and 1.17% for total bleeding events. Annual incidence of ischemic stroke increased with elevated predicted risks based on CHA2DS2-VASc scores 0.18% for low-risk, 0.44% intermediate-risk, and 1.29% high-risk groups (P less then 0.001 for trend). Annual incidences of total bleeding also increased with elevated predicted risks 0.51% for low-risk, 1.28% intermediate-risk, and 2.02% high-risk groups (P less

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Phospha-Wittig reagents, RPPMe3 (R = Mes* 2,4,6-tBu3-C6H2; MesTer 2,6-(2,4,6-Me3C6H2)-C6H3; DipTer 2,6-(2,6-iPr2C6H3)-C6H3), can be considered as phosphine-stabilized phosphinidenes. In this study we show that PMe3 can be displaced by NHCs or NHOs. Interestingly, phosphinidene-like reactivity results in a subsequent C(sp2)-H activation of the exocyclic CH2 group in NHOs. This concept was further extended to allyl-apended NHOs, which resulted in phosphine-substituted allyl species.Owing to a growing awareness towards environmental impact, t