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© 2020 The Authors. Molecular Plant Pathology published by British Society for Plant Pathology and John Wiley Sons Ltd.Dysregulation of lipid homeostasis is intimately involving defects in insulin secretion, an integral function of diabetes. Here, we explore the role of the putative lipid transporter ABCA12 in managing insulin secretion from β-cells. Mice with β-cell-specific deletion of Abca12 screen impaired glucose-stimulated insulin secretion and ultimate islet infection and β-cell death. ABCA12's activ