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namic efficiency of men. Laryngopharyngeal reflux-associated symptoms embrace a wide variety of head and neck manifestations. Its participation in eye disorders has recently been postulated, and there is currently no consensus in this regard. The aim of this manuscript is to review the role of reflux in the development of ocular signs and symptoms, and its physio-pathological mechanisms. A systematic approach based on the preferred reporting Items for a systematic review and meta-analysis checklist with a modified population, intervention,