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DR-MMRM is an encouraging way of dose-response evaluation.DR-MMRM is a promising way for dose-response analysis.Matrix vesicles (MVs) tend to be extracellular membrane-bound vesicles of approximately ~ 50-200 nm in diameter that play a role in the bio-mineralization procedure for hard tissue development. The current review is founded on the empirical trend of main mineralization process via matrix vesicle-mediated mechanism with unique reference to crystal ghosts plus the device reg