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Vital biological processes such as genome repair require fast and efficient binding of selected proteins to specific target sites on DNA. Here we propose an active target search mechanism based on "chromophoresis," the dynamics of DNA-binding proteins up or down gradients in the density of epigenetic marks, or colors (biochemical tags on the genome). We focus on a set of proteins that deposit marks from which they are repelled-a case which is only encountered away from thermodynamic equilibrium. For suitable ranges of k