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ADHD in Adults Undiagnosed Living with undiagnosed ADHD can be a very difficult experience which can lead to years of guilt and low self-esteem. This can lead depression as well as mental health issues and even substance abuse. In contrast to children, diagnosing ADHD in adults requires a thorough medical history that may include a psychological exam and a conversation with closest family members to get their perspective on childhood behavior. 1. Problems in Focusing People suffe