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BACKGROUND AIMS For patients with liver disease from hepatitis C virus (HCV) infection complicated by end-stage renal disease (ESRD), it is important to assess liver fibrosis before kidney transplantation. We evaluated the accuracy of non-invasive tests to identify advanced hepatic fibrosis in patients with HCV and ESRD. METHODS In a retrospective study, we collected data on ratio of aspartate aminotransferasealanine aminotransferase (ASTALT), AST platelet ratio index (APRI), FIB-4 score, fibrosis index sco

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J Res Proteome 161806-1816, 2017).OpenVax is a computational workflow for identifying somatic variants, predicting neoantigens, and selecting the contents of personalized cancer vaccines. It is a Dockerized end-to-end pipeline that takes as input raw tumor/normal sequencing data. It is currently used in three clinical trials (NCT02721043, NCT03223103, and NCT03359239). In this chapter, we describe how to install and use OpenVax, as well as how to interpret the generated results.Tumor neoantigens are at the core of immunological tumor contr