https://www.selleckchem.com/pr....oducts/chk2-inhibito
The endothelial glycocalyx (EG) plays a vital role in the physiology and pathophysiology of human microcirculation. Having relevant EG damage model would be important tool for testing new interventions aiming at EG protection and recovery. We describe the first in vivo EG damage model in pig. To investigate the course of animal EG damage induced by specific enzymes. Four anesthetized piglets received enzymes 1g hyaluronidase and 25 IU heparanase I intravenously. Blood and urine samples were collected at baseline and 20/
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