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VAS scores. MCID achievement varied for PROMIS PF and VAS back, suggesting that though BMI may affect postoperative outcome values, obesity may impact a patient's perception of meaningful improvements in pain and physical function.Convection-enhanced delivery of rhenium-186 (186Re)-nanoliposomes is a promising approach to provide precise delivery of large localized doses of radiation for patients with recurrent glioblastoma multiforme. Current approaches for treatment planning utilizing convection-enhanced delivery are designed for small

Pastor Brian Markle: A Call to Turn Things Right Side Up

As a kid, I used to love the 'jungle gym' - you remember that? We, as the less sophisticated people, called them the monkey bars. And they were rightly named so because we would hang upside down for extended periods of time. Have you ever hung upside down? The world looks different. If you stay in that position for an extended period of time, you'll discover some unusual things happening. Instead of citing all the physiological problems which could occur, just make a note that the big problem is our circulatory system. The way the body is made up with its veins, arteries and heart, it uses gravity to get the blood to your feet and pump the blood to your head. Reverse your body and some damaging things can happen. According to Professor Ashley Grossman of the Barts Medical School (Queen Mary, University of London) this may happen, ''Fluid will start to ease out of your blood vessels, you can't get oxygen, and the lungs will become rather still so you will get breathless.'' By the way, to remain in that position can lead to a stroke or death.

To take an honest look at this great country is to see that things are 'out-of-whack' 'unusual', out of sync, and upside down. We have become like the Apostle Paul and seem to do what we shouldn't while not doing what we should. We seem to declare right, wrong and wrong right (Like Isaiah 5). Why is this? The writer of Proverbs explains it in simple terms. (READ)

It has been said that America will only be great as long as she is good, and when she ceases to be good she will no longer be great. Righteousness is up and sin is supposed to be down - in a normal world. Let's do a broad survey and then bring it back to a very personal conclusion.

Pastor Brian Markle: A Call to Turn Things Right Side Up

As a kid, I used to love the 'jungle gym' - you remember that? We, as the less sophisticated people, called them the monkey bars. And they were rightly named so because we would hang upside down for extended periods of time. Have you ever hung upside down? The world looks different. If you stay in that position for an extended period of time, you'll discover some unusual things happening. Instead of citing all the physiological problems which could occur, just make a note that the big problem is our circulatory system. The way the body is made up with its veins, arteries and heart, it uses gravity to get the blood to your feet and pump the blood to your head. Reverse your body and some damaging things can happen. According to Professor Ashley Grossman of the Barts Medical School (Queen Mary, University of London) this may happen, ''Fluid will start to ease out of your blood vessels, you can't get oxygen, and the lungs will become rather still so you will get breathless.'' By the way, to remain in that position can lead to a stroke or death.

To take an honest look at this great country is to see that things are 'out-of-whack' 'unusual', out of sync, and upside down. We have become like the Apostle Paul and seem to do what we shouldn't while not doing what we should. We seem to declare right, wrong and wrong right (Like Isaiah 5). Why is this? The writer of Proverbs explains it in simple terms. (READ)

It has been said that America will only be great as long as she is good, and when she ceases to be good she will no longer be great. Righteousness is up and sin is supposed to be down - in a normal world. Let's do a broad survey and then bring it back to a very personal conclusion.

Advocate Sounds Alarm Over Expanded Alcohol Sales in Ontario

Ottawa, ON – Brian Markle, a long-time advocate for addiction recovery, is urgently raising concerns about the increased availability of alcohol in Ontario. Recent regulatory changes allowing alcohol sales in convenience stores have sparked fears of rising consumption and associated social issues.

Markle, who has nearly two decades of service with Alcoholics Anonymous (AA), is particularly alarmed by the lack of oversight in convenience stores compared to LCBO outlets. “This change could have significant consequences for individuals and families already struggling with alcohol-related challenges,” he warned.

In response, Markle is rallying community leaders to address the issue. He has scheduled a luncheon to discuss the potential impact of expanded alcohol sales and to strategize on ways to mitigate risks. "We need to act now before this becomes a larger public health concern," Markle said.

Beyond his advocacy against increased alcohol availability, Brian Markle continues his extensive community work. He is currently leading the "100 Turkeys for 100 Families" initiative, a Thanksgiving effort to provide meals to 100 families in need. This charitable drive is a testament to his ongoing dedication to uplifting the community.

Markle’s dual focus on immediate community support and tackling systemic challenges reflects his unwavering commitment to helping vulnerable populations. As the conversation around expanded alcohol sales unfolds, Markle’s leadership is drawing attention to the urgent need for action.

Further updates will follow on this developing story and the outcomes of Markle’s advocacy efforts.

Aston Martin DB12 Goldfinger Edition Celebrates 60 Years of Working with James Bond
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On September 17, 1964, the movie Goldfinger premiered in London, marking the first time an Aston Martin DB5 ever appeared on film. Clearly, it was high time the model made its silver screen debut because 60 years later, the car and the spy are still intimately linked. So much so that Aston Martin has decided to mark the anniversary with the DB12 Goldfinger Edition.

Just like 007, Aston Martin has turned to the Q division to prepare its grand tourer for duty, and the result is a limited edition model, of which just 60 will be sold. Each example of the DB12 Goldfinger Edition will be finished in Silver Birch paint, just like the DB5 that was featured in the film. As a nod to the classic’s wire-spoke rims, the new model has 21-inch multi-spoke wheels that cover black brake callipers.

More than its overall look, the DB12 Goldfinger Edition is also marked by its subtler touches. Its winged logo is finished in silver with black enamel, and it gets bespoke gold side strakes. The gold theme continues inside, where the drive mode dial, the roller controls, and the notched gear selector are all plated in 18K gold, and the carbon fibre trim has gold metal fibres woven into it.

On top of being a nod to the film’s titular villain, Aston Martin says the gold highlights were specifically inspired by the golden tracking device that James Bond uses in the film — and that isn’t where the references stop. Buyers will also find a red number eight and a heart stitched into the driver’s side sunshade, which is the last card drawn during the film’s Miami pool scene.

In addition, the DB12 Goldfinger Edition’s leather Sport Plus seats are finished in the classic DB5 fluted style, and feature a perforation pattern inspired by the Prince of Wales check, the same pattern seen on a notable suit worn by Bond. The pattern is also found on the door inserts, the headliner, and is etched onto the car’s treadplates.

Finally, buyers will be offered a selection of gifts, including a Globe-Trotter attaché case and Air Cabin Case, the latter of which can hold the magnum of 2007 vintage Champagne Bollinger and the Bollinger 007 glasses that buyers are also entitled to. In addition, buyers will get a Silver Birch Speedform model and a section of 35mm film that features a portion of the Furka Pass scene from the movie Goldfinger. Finally, buyers will receive a special, 1 of 60 golden edition of Aston Martin magazine to read next to their vehicle.