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A literature-based and database study of this the different parts of Rhizoma coptidis had been done and screened by ADME variables. The targets of Rhizoma coptidis were predicted because of the ligand similarity strategy. Relevant pathways were examined with databases, and pc software was used to make a "component/target/path" network. The process had been more confirmed by GEO database with R computer software. A total of 12 active elements had