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How to Care For a Purebred German Shepherd Puppy German Shepherds are one of the most well-known breeds in America. They make great pets for families and as working dogs. German Shepherd puppies have thick double coats that shed a lot in the spring and summer. Brushing frequently using a deshedding rake or undercoat rake can reduce shedding, and keep the coat looking shiny and healthy. Health German Shepherds have a few health issues, but are generally healthy and intelligent dogs. B

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Disability accrual in multiple sclerosis may occur as relapse-associated worsening or progression independent of relapse activity. The role of progression independent of relapse activity in early multiple sclerosis is yet to be established. The objective of this multicentre, observational, retrospective cohort study was to investigate the contribution of relapse-associated worsening and progression independent of relapse activity to confirmed disability accumulation in patients with clinically isolated syndrome and early relapsing-remitt