https://www.selleckchem.com/btk.html
WWP1 is an E3 ubiquitin ligase that has been reported to target the tumor suppressor lipid phosphatase PTEN. K740N and N745S are recently identified germline variants of WWP1 that have been linked to PTEN-associated cancers [Lee, Y. R., et al. (202 N. Engl. J. Med.]. These WWP1 variants have been suggested to release WWP1 from its native autoinhibited state, thereby promoting enhanced PTEN ubiquitination as a mechanism for driving cancer. Using purified proteins and in vitro enzymatic assays, we investigate the possibility that K740N and N745S WWP

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Top Signs of ADHD in Adults Many people suffering from ADHD aren't diagnosed even if the symptoms were evident when they were children. They may feel content to receive a diagnosis, knowing they're not in a hurry or unwilling to change. Adult ADHD symptoms can be harder to recognize than those in children and often are masked with other mental health issues like depression or anxiety. The symptoms are also more difficult to miss if you're busy with work and household responsibilities. 1. You Can't Focus Being unable to stay focused and organized is a