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In this review, we will summarize knowledge of the ATX-LPA axis and its role in the development of resistance to chemotherapy and radiotherapy. We will also offer insights for developing strategies of targeting ATX-LPA axis as a novel part of cancer treatment. This article is part of a Special Issue entitled Lysophospholipids and their receptors New data and new insights into their function edited by Susan Smyth, Viswanathan Natarajan and Colleen McMullen. BACKGROUND Simulation is an important teaching strategy in the preparation of nursi
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