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Should You Buy an Old German Shepherd Dog? German Shepherds are employed in various scent-work roles such as cadaver search, narcotics and explosives detection. These jobs may require a lot of obedience and protective training. Responsible breeders pair up their best adult dogs, check their dogs of genetic health issues and raise puppies under optimal conditions. Breeders who are responsible charge a premium for their services. Health Old German Shepherd Dogs are healthier than modern German Shepherd Dogs, becau

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Osteoporosis is frequently accompanied by iron disorders. Calcitonin (CT) was approved as a clinical drug to treat osteoporosis. Hepcidin is a peptide hormone that is secreted by the liver and controls body iron homeostasis. Hepcidin deficiency leads to iron overload diseases. This study was aimed at investigating the effect of CT on hepatic hepcidin and the mechanism by which CT modulates hepatic hepcidin pathways and iron metabolism. RT-PCR, Western blot, ELISA and siRNA were used to detect the effect of CT on iron metabolism in vivo an