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We focus our discussion around recent experiences from the International Traumatic Brain Injury Research (InTBIR) initiative, with a specific focus on 4 major clinical projects (TRACK-TBI, CENTER-TBI, CREACTIVE and ADAPT), which are currently enrolling subjects in North America and Europe. We discuss common data elements, data collection efforts, data-sharing opportunities and challenges, and examine the statistical techniques required to realize successful adoption and use of biomarkers in the clinic as a foundation for precision m

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