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stigated. The study is expected to provide new knowledge on the effectiveness of a comprehensive rehabilitation model that incorporates early identification of patients with musculoskeletal pain at risk for development of sickness absence and persistent pain. The study findings may contribute to more effective rehabilitation processes of this large patient population, and potentially reduce sickness absence and costs. ClinicalTrials.gov Protocol ID NCT03913325 , Registered April 12, 2019. Version 2, 10 July 2020. Version 2 chang