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Aim To compare the pathogenesis of vulvovaginal candidiasis by three Candida species in diabetic mice. Materials methods Estrogenized and diabetic mice were challenged with C. albicans, C. tropicalis and C. glabrata. Results Diabetic animals infected with C. albicans and C. tropicalis maintained the highest fungal burden, despite of high levels of proinflammatory cytokines (IL-6 and TNF-α), respectively. For C. glabrata, the results were similar in diabetic and nondiabetic groups. ConclusionC. tropicalis was as invasive as C. albican