https://www.selleckchem.com/products/sd49-7.html
Intermediate filaments (IFs) perform a diverse set of well-known functions including providing structural support for the cell and resistance to mechanical stress, yet recent evidence has revealed unexpected roles for IFs as stress response proteins. Previously, it was shown that the type III IF protein vimentin forms cage-like structures around centrosome-associated proteins destined for degradation, structures referred to as aggresomes, suggesting a role for vimentin in protein turnover. However, vimentin's function at the aggresome ha

https://www.selleckchem.com/products/tram-34.html
In Nf1 spines, MEKi increased bone volume (+194%, P0.001) whereas ZA increased bone density (+10%, P0.002) versus BMP-2 alone. Both MEKi and ZA decreased TRAP+cells in the fibrous tissue (MEKi-62%, P0.01; ZA-43%, P=0.054). No adverse effects were seen with either MEKi or ZA treatment including weight loss or signs of illness or distress that led to premature euthanasia. These data not only support the utility of an AdCre-virus induced knockout spine model, but also support further investigation of MEKi and ZA as adjunctive t