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Reactive oxygen species and LDs induced by the deprivation of Met and Tyr were prevented in hepatic organoids generated from Keap1∆hepa . Dimethyl fumarate, a Nrf2 inducer ameliorated the steatosis and increased the hepatic fumarate reduced by the deprivation of Met and Tyr in vitro. OA / Met or Tyr ratio in peripheral blood were associated with the hepatic steatosis in NAFLD patients. CONCLUSION An imbalance between free fatty acids and Met and Tyr induces hepatic steatosis by disturbing the VLDL assembling via the Keap1-Nrf2 system. Li
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