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Environmental and individual risk factors make leishmaniasis an important public health problem. Presently, there are several medicines existing for the cure of leishmaniasis, but a major problem associated with them is their adverse effects. The affinity to the fucose receptor increases the phagocytosis of ligand-bound carriers and simultaneously targets the delivery of the antileishmanial agent. Paromomycin sulphate-bearing nanostructured lipid carriers (NLCs) were formulated by a double emulsion solvent evaporation technique,