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82 (95% confidence interval 0.72-0.88). The cut-off values of DTF for prediction of NIV failure were  36.3% and  37.1% for the operator 1 and 2 (p  0.0001), respectively. The cut-off value of respiratory rate/DTF ratio for prediction of NIV failure was  0.6 for both operators (p  0.0001). DTF and respiratory rate/DTF ratio may both represent valid, feasible and noninvasive tools to predict NIV outcome in patients with de-novo ARF. Trial registration ClinicalTrials.gov Identifier NCT02976233, registered 26 November 2

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Alzheimer's disease (AD) is the most common neurodegenerative disorder worldwide. The association between AD and other diseases such as diabetes is well-studied. In parallel, potential disease-modifying effects of therapeutic agents used for diabetes have been investigated in the context AD of. Metformin is a biguanide and the most commonly prescribed medication for type 2 diabetes Due to its pleiotropic properties, metformin's potential disease-modifying effects are widely studied on different pathophysiological plyers of AD such