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•Mast cells are plentiful in cardiac tissue and may lead to coronary artery/stent thrombosis. •A prototypical patient with Kounis syndrome who experienced allergy symptoms and myocardial ischemia after being exposed to a probable allergenic stimulus.•A link between Type III Kounis syndrome and drug-eluting stent thrombosis has recently been hypothesized.•Mast cells are plentiful in cardiac tissue and may lead to coronary artery/stent thrombosis. Duchenne muscular dystrophy (DMD) is a congenital X-linked muscular dystrophy,