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Notably, the increase of base substitutions in the homologous recombination-deficient Rad51 mutant, specifically dependent on the Polζ translesion polymerase, yields COSMIC signature 3 observed in BRCA1/BRCA2-mutant breast cancer tumors. Furthermore, "mutome" analyses in highly polymorphic diploids and single-cell bottleneck lineages revealed a diverse spectrum of loss-of-heterozygosity (LOH) signatures characterized by interstitial and terminal chromosomal events resulting from interhomolog mitotic cross-overs. Following the appear

https://vendelbo-patrick.mdwri....te.net/some-wisdom-o
Why Choose a Composite Door Replacement? A composite door is a great choice for your home as it offers a variety of advantages, including security, aesthetics, and energy efficiency. Like all front doors it is not without its flaws. Fortunately the issues are simple to resolve, so you can enjoy your composite door for longer. Durability Composite doors are an excellent option to protect your home and look gorgeous. Unlike wooden doors, they are not susceptible to warping or rotting i