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We investigate the use of the so-called variably scaled kernels (VSKs) for learning tasks, with a particular focus on support vector machine (SVM) classifiers and kernel regression networks (KRNs). Concerning the kernels used to train the models, under appropriate assumptions, the VSKs turn out to be more expressive and more stable than the standard ones. Numerical experiments and applications to breast cancer and coronavirus disease 2019 (COVID-19) data support our claims. For the practical implementation of the VSK